| http://purl.uniprot.org/citations/19884327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19884327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19884327 | http://www.w3.org/2000/01/rdf-schema#comment | "The microenvironment hosting a tumor actively participates in regulating tumor cell proliferation, migration, and invasion. Among the extracellular matrix proteins enriched in the stroma of carcinomas are the tenascin family members tenascin-C and tenascin-W. Whereas tenascin-C overexpression in gliomas is known to correlate with poor prognosis, the status of tenascin-W in brain tumors has not been investigated so far. In the present study, we analyzed protein levels of tenascin-W in 38 human gliomas and found expression of tenascin-W in 80% of the tumor samples, whereas no tenascin-W could be detected in control, nontumoral brain tissues. Double immunohistochemical staining of tenascin-W and von Willebrand factor revealed that tenascin-W is localized around blood vessels, exclusively in tumor samples. In vitro, the presence of tenascin-W increased the proportion of elongated human umbilical vein endothelial cells (HUVECs) and augmented the mean speed of cell migration. Furthermore, tenascin-W triggered sprouting of HUVEC spheroids to a similar extent as the proangiogenic factor tenascin-C. In conclusion, our study identifies tenascin-W as a candidate biomarker for brain tumor angiogenesis that could be used as a molecular target for therapy irrespective of the glioma subtype.-Martina, E., Degen, M., Rüegg, C., Merlo, A., Lino, M. M., Chiquet-Ehrismann, R., Brellier, F. Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-140491"xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-140491"xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Martina E."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Martina E."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Degen M."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Degen M."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Rueegg C."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Rueegg C."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Chiquet-Ehrismann R."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Chiquet-Ehrismann R."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Merlo A."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Merlo A."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Brellier F."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Brellier F."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Lino M.M."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/author | "Lino M.M."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/pages | "778-787"xsd:string |
| http://purl.uniprot.org/citations/19884327 | http://purl.uniprot.org/core/pages | "778-787"xsd:string |