| http://purl.uniprot.org/citations/19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19886839 | http://www.w3.org/2000/01/rdf-schema#comment | "The CCR5Delta32 mutation does not account for HIV-1 resistance in the majority of persons who are repeatedly exposed to HIV-1 by high-risk activities but remain seronegative and uninfected. Therefore, we investigated the impact of CCR5 59029 A/G and CCL3L1 copy number polymorphism on HIV-1 disease susceptibility and progression among HIV-1-infected and HIV-1-exposed seronegative North Indians. HIV-1-seropositive (HSP, n = 196) patients, stratified on the basis of disease severity (Stages I, II, and III) and HIV-1-exposed seronegative (HES, n = 47) individuals were genotyped for CCR5-59029 A/G polymorphism by PCR-RFLP and CCL3L1 copy number by the real-time TaqMan PCR method. A group of ethnically matched HIV-1-seronegative (HSN, n = 315) healthy volunteers were also genotyped as controls. Statistical analysis was done by SPSS software. The CCR5-59029 AG genotype was significantly higher in the HES compared with the HSP group (57.44% vs. 37.24%, p = 0.014). The CCL3L1 mean copy number of HES was higher compared with the HSP groups (3.148 +/-0.291 vs. 2.795 +/-0.122, p = 0.212), but was not significant when compared with independent samples t test. Possession of CCL3L1 copies < or = 2 or >2 was not associated with enhanced or reduced risk of HIV-1 acquisition. Gene-gene interaction studies showed enrichment of the CCR5-59029AG*CCL3L1>2 genotype in the HES group when compared with the HSP group (31.91% vs. 15.81%, p = 0.021, OR = 0.401, CI = 0.194-0.826). The increased frequency of the CCR5-59029AG*CCL3L1>2 genotype among HES individuals led us to conclude that the CCR5-59029 AG genotype and CCL3L1 gene dose appeared to have synergistic or interactive effects and are expected to be involved in the host innate resistance to HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.org/dc/terms/identifier | "doi:10.1089/aid.2008.0019"xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Chatterjee A."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Yamamoto N."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Rathore A."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Dhole T.N."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Sivarama P."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/author | "Singhal P.K."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/pages | "1149-1156"xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/title | "Association of CCR5-59029 A/G and CCL3L1 copy number polymorphism with HIV type 1 transmission/progression among HIV type 1-seropositive and repeatedly sexually exposed HIV type 1-seronegative North Indians."xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/19886839 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19886839 |
| http://purl.uniprot.org/citations/19886839 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G3K0-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-19886839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19886839 |