| http://purl.uniprot.org/citations/19889952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19889952 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal blood flow (RBF) autoregulation is mediated by at least two mechanisms, the fast acting myogenic response (approximately 5 s) and slow acting tubuloglomerular feedback (TGF; approximately 25 s). Previous studies suggest epithelial Na(+) channel (ENaC) family proteins, beta-ENaC in particular, mediate myogenic constriction in isolated renal interlobar arteries. However, it is unknown whether beta-ENaC-mediated myogenic constriction contributes to RBF autoregulation in vivo. Therefore, the goal of this investigation was to determine whether the myogenic mediated RBF autoregulation is inhibited in a mouse model of reduced beta-ENaC (m/m). To address this goal, we evaluated the temporal response of RBF and renal vascular resistance (RVR) to a 2-min step increase in mean arterial pressure (MAP). Pressure-induced changes in RBF and RVR at 0-5, 6-25, and 110-120 s after step increase in MAP were used to assess the contribution of myogenic and TGF mechanisms and steady-state autoregulation, respectively. The rate of the initial increase in RVR, attributed to the myogenic mechanism, was reduced by approximately 50% in m/m mice, indicating the speed of the myogenic response was inhibited. Steady-state autoregulation was similar between beta-ENaC +/+ and m/m mice. Although the rate of the secondary increase in RVR, attributed to TGF, was similar in beta-ENaC +/+ and m/m mice, however, it occurred over a longer period (+10 s), which may have allowed TGF to compensate for a loss in myogenic autoregulation. Our findings suggest beta-ENaC is an important mediator of renal myogenic constriction-mediated RBF autoregulation in vivo."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00496.2009"xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/author | "Ryan M.J."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/author | "Drummond H.A."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/author | "Grifoni S.C."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/author | "McKey S.E."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/author | "Chiposi R."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/pages | "F285-92"xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/title | "Altered whole kidney blood flow autoregulation in a mouse model of reduced beta-ENaC."xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://purl.uniprot.org/core/volume | "298"xsd:string |
| http://purl.uniprot.org/citations/19889952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19889952 |
| http://purl.uniprot.org/citations/19889952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19889952 |
| http://purl.uniprot.org/uniprot/#_A2RS45-mappedCitation-19889952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19889952 |
| http://purl.uniprot.org/uniprot/#_Q3TP51-mappedCitation-19889952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19889952 |
| http://purl.uniprot.org/uniprot/#_Q9WU38-mappedCitation-19889952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19889952 |
| http://purl.uniprot.org/uniprot/Q3TP51 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19889952 |
| http://purl.uniprot.org/uniprot/A2RS45 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19889952 |
| http://purl.uniprot.org/uniprot/Q9WU38 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19889952 |