| http://purl.uniprot.org/citations/19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19890042 | http://www.w3.org/2000/01/rdf-schema#comment | "Effector Th17 cells are a major source of IL-17, a critical inflammatory cytokine in autoimmune diseases and in host defenses during bacterial infections. Recently, splenic lymphoid tissue inducer-like cells have been reported to be a source of T cell independent IL-17. In this study, we report that the immune system contains a unique set of natural occurring IL-17 producing cell, "natural" Th17 (nTh17), which are a memory-like T cell subset. The nTh17 cells can develop in the absence of the IL-6/STAT3 signaling axis required by inducible Th17 cells. The nTh17 cell population is distinct from conventional inducible Th17 cells, since nTh17 cells express substantial amounts of IL-17A (IL-17), but not IL-17F, under the control of the master regulator, RORgammat. The nTh17 cells simultaneously produce IFN-gamma. DO11.10 transgenic mice with a Rag(-/-) background (DO11.10 Rag(-/-)) lack nTh17 cells, and, following intranasal administration of OVA, IL-17-dependent neutrophil infiltration occurs in DO11.10 transgenic mice, but not in DO11.10 Rag(-/-) mice. The impaired neutrophil-dependent airway response is restored by adaptive transfer of nTh17 cells into DO11.10 Rag(-/-) mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803828"xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Naka T."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Nakae S."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/author | "Cua D."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/pages | "7523-7530"xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/title | "Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses."xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19890042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19890042 |
| http://purl.uniprot.org/citations/19890042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-19890042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19890042 |