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http://purl.uniprot.org/citations/19890662http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19890662http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Since apoptosis may play a role in the prognosis of breast cancer, the present study analyzed the polymorphisms of apoptosis-related genes and their impact on the survival of 240 patients with early invasive ductal breast cancer.

Methods

The genomic DNA was extracted from paraffin-embedded tumor-free tissue or blood, and 12 single nucleotide polymorphisms (SNPs) of 11 apoptosis-related genes in the apoptosis pathway determined using a Sequenom MassARRAY system.

Results

During the median follow-up of 53.4 (range 2.9-205.9) months, 37 relapses and 22 deaths occurred. Among the target polymorphisms, the tumor necrosis factor superfamily member 10 gene polymorphism (TNFSF10 rs1131532) in a recessive model of the T allele and prostaglandin-endoperoxide synthase 2 gene polymorphism (PTGS2 rs5275) in a dominant model of the C allele were associated with survival in a log-rank test. The TT genotype of TNFSF10 (rs1131532) was also significantly correlated with a lower disease-free, distant disease-free, and overall survival in a multivariate analysis (HR = 3.304, 4.757, and 6.459; P = 0.002, 0.001, and 0.009, respectively), while PTGS2 rs5275 was only associated with a higher distant disease-free survival (HR = 0.302; P = 0.041). No clinicopathologic difference was observed according to the genotypes of these two polymorphisms.

Conclusion

The TNFSF10 (rs1131532) polymorphism was identified as a possible prognostic factor of survival in patients with operated invasive breast cancer."xsd:string
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http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Jung J.H."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Lee M.H."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Park J.Y."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Moon J.H."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Park H.Y."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Kim J.G."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Chae Y.S."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Sohn S.K."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/author"Kang B.W."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/name"J Cancer Res Clin Oncol"xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/pages"685-694"xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/title"TNF superfamily gene polymorphism as prognostic factor in early breast cancer."xsd:string
http://purl.uniprot.org/citations/19890662http://purl.uniprot.org/core/volume"136"xsd:string
http://purl.uniprot.org/citations/19890662http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19890662
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