| http://purl.uniprot.org/citations/19890848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19890848 | http://www.w3.org/2000/01/rdf-schema#comment | "Self-renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB-dependent growth control. We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220(NPAT)/HiNF-P complex to activate histone gene expression at the G1/S phase transition. We show that cyclin D2 is prominently expressed in pluripotent hES cells, but cyclin D1 eclipses cyclin D2 during differentiation. Depletion of cyclin D2 or p220(NPAT) causes a cell cycle defect in G1 reflected by diminished phosphorylation of p220(NPAT), decreased cell cycle dependent histone H4 expression and reduced S phase progression. Thus, cyclin D2 and p220(NPAT) are principal cell cycle regulators that determine competency for self-renewal in pluripotent hES cells. While pRB/E2F checkpoint control is relinquished in human ES cells, fidelity of physiological regulation is secured by cyclin D2 dependent activation of the p220(NPAT)/HiNF-P mechanism that may explain perpetual proliferation of hES cells without transformation or tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21967"xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "Becker K.A."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "Lian J.B."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/author | "Ghule P.N."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/pages | "456-464"xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/title | "Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/19890848 | http://purl.uniprot.org/core/volume | "222"xsd:string |
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