| http://purl.uniprot.org/citations/19895570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19895570 | http://www.w3.org/2000/01/rdf-schema#comment | "Major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located within the human MHC, centromeric to HLA-B and telomeric to HLA-DRB1. The location of MICA in the MHC indicates the presence of linkage disequilibrium with human leukocyte antigen (HLA). Like HLA, MICA is highly polymorphic; however, the information available for MICA polymorphisms is not as comprehensive as that for HLA polymorphisms. We estimated the allelic frequencies of MICA and haplotypes with HLA-B and HLA-DRB1 at high-resolution in a population of 139 unrelated Korean individuals by applying the newly developed method of sequence-based typing (SBT). A total of 17 MICA alleles were identified. The most frequent allele was MICA*010 (19.4%), followed by alleles *00201 (17.6%), *00801 (14.7%), *01201 (9.4%), *004 (8.3%) and *049 (7.9%). The most common two- and three-locus haplotypes were HLA-B*1501-MICA*010 (10.4%), MICA*010-HLA-DRB1*0406 (5.8%) and HLA-B*1501-MICA*010-HLA-DRB1*0406 (5.8%). This is the first study to provide such high-resolution information on the distribution of haplotypes comprising MICA, HLA-B and HLA-DRB1 in Korean individuals, a level of resolution made possible by use of the SBT method. The results of this study should help determine the mechanisms underlying diseases associated with MICA polymorphisms in Korean individuals."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2009.01396.x"xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Oh H.B."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Kim M.H."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Choi S.E."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Kwon O.J."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Sohn Y.H."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/author | "Cha C.H."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/pages | "48-55"xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/title | "MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans."xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/19895570 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19895570 |
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