| http://purl.uniprot.org/citations/19896466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19896466 | http://www.w3.org/2000/01/rdf-schema#comment | "Junctate is a newly identified sarcoplasmic reticulum (SR) Ca(2+) binding protein, but its function in cardiac muscle has remained unclear. Our previous study showed that chronic over-expression of junctate in transgenic mice led to altered SR functions and development of severe hypertrophy. In this study, we identified the interaction of junctate with SERCA2a by co-immunoprecipitation and GST-pull-down assay. This interaction was inhibited by higher Ca(2+) concentration. Immunolocalization assays also showed that junctate and SERCA2a were co-localized in the SR of cardiomyocytes. Direct binding of the C-terminal region of junctate (amino acids 79-270) and luminal domain of SERCA2a (amino acids 70-89) was observed by deletion mutation experiments. Adenovirus-mediated transient over-expression of junctate in cardiomyocytes showed a reduced decay time of Ca(2+) transients and increased oxalate-supported SERCA2 Ca(2+) uptake, suggesting an increased activity of SERCA2a. Taken together, according to our data, junctate may play an important role in the regulation of SR Ca(2+) cycling through the interaction with SERCA2a in the murine heart."xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.10.165"xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/author | "Kwon S.J."xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/pages | "1389-1394"xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/title | "Characterization of junctate-SERCA2a interaction in murine cardiomyocyte."xsd:string |
| http://purl.uniprot.org/citations/19896466 | http://purl.uniprot.org/core/volume | "390"xsd:string |
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