| http://purl.uniprot.org/citations/19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19896562 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis.MethodsA total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model.ResultsA total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p<0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p<0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p<0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p=0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p<0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence (221)VHFFKNIVT(229) was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503.ConclusionThe current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.autrev.2009.11.001"xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Patarroyo M.A."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Sanchez J.L."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Anaya J.M."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Rojas-Villarraga A."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Cruz-Tapias P."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Rojas O.L."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/author | "Suarez-Escudero J.C."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/name | "Autoimmun Rev"xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/pages | "407-413"xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/title | "HLA class II polymorphism in Latin American patients with multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19896562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19896562 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-19896562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19896562 |
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