http://purl.uniprot.org/citations/19897003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19897003 | http://www.w3.org/2000/01/rdf-schema#comment | "Killer cell immunoglobulin-like receptors (KIR) control the effector function of natural killer (NK) cells and subsets of T cell, and the genes encoding KIRs are substantially variable among individuals. A majority (58.4%) of Japanese individuals were found to be homozygous for group A KIR haplotypes that encode only a single activating KIR2DS4. Contrarily, most of Japanese patients with Vogt-Koyanagi-Harada (VKH) disease (69.2%), a panuveitis carry Bx genotypes that encode 2-5 activating KIR receptors. Particularly, individuals carrying three activating KIR genes 3DS1, 2DS1, and 2DS5 are more frequent in patient group compared with the controls (42.2% vs 21.4%, p = 0.02). In addition, the inhibitory KIR gene 3DL1 was significantly decreased in patients compared with controls (76.9% vs 98.8%, p = 0.00006). These data suggest that the genotypes encoding a dominant activating KIR receptor repertoire predispose susceptibility to VKH disease."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2009.11.001"xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/author | "Keino H."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/author | "Rajalingam R."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/author | "Ashouri E."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/author | "Okada A.A."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/author | "Levinson R.D."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/pages | "192-194"xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/title | "Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals."xsd:string |
http://purl.uniprot.org/citations/19897003 | http://purl.uniprot.org/core/volume | "71"xsd:string |
http://purl.uniprot.org/citations/19897003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19897003 |
http://purl.uniprot.org/citations/19897003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19897003 |
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