| http://purl.uniprot.org/citations/19898473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19898473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19898473 | http://www.w3.org/2000/01/rdf-schema#comment | "Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and proinflammatory cytokines in different ways. Degradative ubiquitination of TRAF3 during MyD88-dependent TLR signaling was essential for the activation of mitogen-activated protein kinases (MAPKs) and production of inflammatory cytokines. In contrast, TRIF-dependent signaling triggered noncanonical TRAF3 self-ubiquitination that activated the interferon response. Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1819"xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1819"xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Mino T."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Mino T."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Tseng P.H."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/author | "Tseng P.H."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/pages | "70-75"xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/pages | "70-75"xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/title | "Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/19898473 | http://purl.uniprot.org/core/title | "Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines."xsd:string |