| http://purl.uniprot.org/citations/19898480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19898480 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA-DRB1 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated peptides (CCP). Here, we test the hypothesis that a subset of the anti-CCP response, with specific autoimmunity to citrullinated alpha-enolase, accounts for an important portion of these associations. In 1,497 individuals from three RA cohorts, antibodies to the immunodominant citrullinated alpha-enolase CEP-1 epitope were detected in 43-63% of the anti-CCP-positive individuals, and this subset was preferentially linked to HLA-DRB1*04. In a case-control analysis of 1,000 affected individuals and 872 controls, the combined effect of shared epitope, PTPN22 and smoking showed the strongest association with the anti-CEP-1-positive subset (odds ratio (OR) of 37, compared to an OR of 2 for the corresponding anti-CEP-1-negative, anti-CCP-positive subset). We conclude that citrullinated alpha-enolase is a specific citrullinated autoantigen that links smoking to genetic risk factors in the development of RA."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.480"xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Alfredsson L."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Lundberg K."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Padyukov L."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Charles P."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Ding B."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Plant D."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Klareskog L."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Malmstrom V."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Ronnelid J."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Venables P.J."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Kallberg H."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Symmons D.P."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Fisher B.A."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/author | "Mahdi H."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/pages | "1319-1324"xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/title | "Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/19898480 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19898480 |
| http://purl.uniprot.org/citations/19898480 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19898480 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19898480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19898480 |