| http://purl.uniprot.org/citations/19898482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19898482 | http://www.w3.org/2000/01/rdf-schema#comment | "Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted by the high incidence of irreversible ototoxicity associated with it. In children, cisplatin ototoxicity is a serious and pervasive problem, affecting more than 60% of those receiving cisplatin and compromising language and cognitive development. Candidate gene studies have previously reported associations of cisplatin ototoxicity with genetic variants in the genes encoding glutathione S-transferases and megalin. We report association analyses for 220 drug-metabolism genes in genetic susceptibility to cisplatin-induced hearing loss in children. We genotyped 1,949 SNPs in these candidate genes in an initial cohort of 54 children treated in pediatric oncology units, with replication in a second cohort of 112 children recruited through a national surveillance network for adverse drug reactions in Canada. We identified genetic variants in TPMT (rs12201199, P value = 0.00022, OR = 17.0, 95% CI 2.3-125.9) and COMT (rs9332377, P value = 0.00018, OR = 5.5, 95% CI 1.9-15.9) associated with cisplatin-induced hearing loss in children."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.478"xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Brown A.M."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Lim J."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Inoue M."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Ng D."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Brooks B."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Zhang L.H."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Murray M."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Chan S."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Ross C.J."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Barhdadi A."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Dube M.P."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Hayden M.R."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Visscher H."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Sakaguchi S."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Carter C."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Ross C."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Lau L."xsd:string |
| http://purl.uniprot.org/citations/19898482 | http://purl.uniprot.org/core/author | "Rieder M.J."xsd:string |