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http://purl.uniprot.org/citations/19898927http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19898927http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1.

Methods

Levels of both genital mucosal and blood chemokines were compared between 58 HIV-1-uninfected and 50 HIV-1-infected female commercial sex workers (CSWs) as well as 53 HIV-1-uninfected non-CSW control women at low risk for exposure, recruited in Cotonou, Benin.

Results

HIV-1-infected CSWs had significantly higher blood and genital levels of monocyte chemotactic protein (MCP-3/CCL7) and monokine induced by gamma interferon (MIG/CXCL9) compared with those in both the HIV-1-uninfected CSW and non-CSW groups. In the HIV-1-infected group, levels of MCP-3 and MIG were significantly higher in the genital mucosa than in the blood. However, the blood levels of macrophage inflammatory protein (MIP-1a/CCL3) and MIP-1b/CCL4 were higher in HIV-1-uninfected CSWs compared with those in the other groups.

Conclusion

Increased production of chemokines in the genital tract may favour the recruitment of HIV-1 target cells causing a mucosal environment that promotes viral replication and dissemination, whereas higher expression of beta-chemokines at the systemic level is associated with protection from HIV-1 infection."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.org/dc/terms/identifier"doi:10.1007/s10875-009-9343-3"xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Poudrier J."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Lajoie J."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Roger M."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Alary M."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Labbe A.C."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Leblond F."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Guedou F."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/author"Massinga Loembe M."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/name"J Clin Immunol"xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/pages"90-98"xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/title"Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin."xsd:string
http://purl.uniprot.org/citations/19898927http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/19898927http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19898927
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http://purl.uniprot.org/uniprot/#_Q07325-mappedCitation-19898927http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19898927
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http://purl.uniprot.org/uniprot/P80098http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19898927
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