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http://purl.uniprot.org/citations/1989986http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1989986http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1989986http://www.w3.org/2000/01/rdf-schema#comment"The complete primary structure of a galactose-specific lectin contained in the venom of the rattlesnake, Crotalus atrox, was determined. The lectin is composed of two covalently linked, identical subunits, each consisting of 135 amino acid residues. Under physiological conditions the lectin proved to be highly aggregated. The venom lectin contained 9 half-cystines, 8 of which formed four intrasubunit disulfide bridges (Cys3-Cys14, Cys31-Cys131, Cys38-Cys133, and Cys106-Cys123), while Cys86 was involved in an intersubunit disulfide bridge. Because of the high content of disulfide bridges, the intact lectin was extremely resistant to tryptic digestion. The determined amino acid sequence was found to be homologous with those of the so-called carbohydrate recognition domains of Ca2(+)-dependent-type lectins in animal. Among them, 8 amino acid residues (Cys31, Gly69, Trp92, Pro97, Cys106, Asp120, Cys123, and Cys131) were completely conserved. Leu40, Trp67, and Trp81 were also well conserved. The rattlesnake venom lectin showed high hemagglutinating activity. These results, together with the occurrence of similar lectins in crotalid venoms, suggest that these lectins have evolved in order to make the venom a more effective weapon to capture prey animals."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)52246-8"xsd:string
http://purl.uniprot.org/citations/1989986http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)52246-8"xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Hirabayashi J."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Hirabayashi J."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Kasai K."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Kasai K."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Kusunoki T."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/author"Kusunoki T."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/pages"2320-2326"xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/pages"2320-2326"xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/title"Complete primary structure of a galactose-specific lectin from the venom of the rattlesnake Crotalus atrox. Homologies with Ca2(+)-dependent-type lectins."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/title"Complete primary structure of a galactose-specific lectin from the venom of the rattlesnake Crotalus atrox. Homologies with Ca2(+)-dependent-type lectins."xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/volume"266"xsd:string
http://purl.uniprot.org/citations/1989986http://purl.uniprot.org/core/volume"266"xsd:string
http://purl.uniprot.org/citations/1989986http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1989986
http://purl.uniprot.org/citations/1989986http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1989986
http://purl.uniprot.org/citations/1989986http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1989986
http://purl.uniprot.org/citations/1989986http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1989986