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http://purl.uniprot.org/citations/19901094http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19901094http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19901094http://www.w3.org/2000/01/rdf-schema#comment"The emergence of bla(VIM-1) within four different genetic platforms from distinct Enterobacteriaceae and Pseudomonas aeruginosa isolates in an area with a low prevalence of metallo-beta-lactamase producers is reported. Forty-three VIM-1-producing isolates (including 19 Enterobacter cloacae, 2 Escherichia coli, and 2 P. aeruginosa isolates, 18 Klebsiella pneumoniae isolate, and 2 Klebsiella oxytoca isolate) recovered from 2005 to 2007 and corresponding to 15 pulsed-field gel electrophoresis types were studied. The Enterobacteriaceae isolates corresponded to a hospital outbreak, and the P. aeruginosa isolates were sporadically recovered. The genetic context of the integrons carrying bla(VIM-1) (arbitrarily designated types A, B, C, and D) was characterized by PCR mapping based on known Tn402 and mercury transposons and further sequencing. Among Enterobacteriaceae isolates, bla(VIM-1) was part of integrons located either in an In2-Tn402 element linked to Tn21 (type A; In110-bla(VIM-1)-aacA4-aadA1) or in a Tn402 transposon lacking the whole tni module [type B; In113-bla(VIM-1)-aacA4-dhfrII (also called dfrB1)-aadA1-catB2] and the transposon was associated with an IncHI2 or IncI1 plasmid, respectively. Among P. aeruginosa isolates, bla(VIM-1) was part of a new gene cassette array located in a defective Tn402 transposon carrying either tniBDelta3 and tniA (type C; bla(VIM-1)-aadA1) or tniC and DeltatniQ (type D; bla(VIM-1)-aadB), and both Tn402 variants were associated with conjugative plasmids of 30 kb. The dissemination of bla(VIM-1) was associated with different genetic structures and bacterial hosts, depicting a complex emergence and evolutionary network scenario in our facility, Ramón y Cajal University Hospital, Madrid, Spain. Knowledge of the complex epidemiology of bla(VIM-1) is necessary to control this emerging threat."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.org/dc/terms/identifier"doi:10.1128/AAC.00783-09"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.org/dc/terms/identifier"doi:10.1128/aac.00783-09"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Baquero F."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Baquero F."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Tato M."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Tato M."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Canton R."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Canton R."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Coque T.M."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/author"Coque T.M."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/name"Antimicrob. Agents Chemother."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/name"Antimicrob Agents Chemother"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/pages"320-327"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/pages"320-327"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/title"Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/title"Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa."xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/19901094http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/19901094http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19901094
http://purl.uniprot.org/citations/19901094http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19901094
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