| http://purl.uniprot.org/citations/19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19906855 | http://www.w3.org/2000/01/rdf-schema#comment | "In the nematode Caenorhabditis elegans, sex is determined by the ratio of X chromosomes to sets of autosomes: XX animals (2X:2A=1.0) develop as hermaphrodites and XO animals (1X:2A=0.5) develop as males. TRA-1, the worm ortholog of Drosophila Cubitus interruptus and mammalian Gli (Glioma-associated homolog) proteins, is the terminal transcription factor of the C. elegans sex-determination pathway, which specifies hermaphrodite fate by repressing male-specific genes. Here we identify a consensus TRA-1 binding site in the regulatory region of xol-1, the master switch gene controlling sex determination and dosage compensation. xol-1 is normally expressed in males, where it promotes male development and prevents dosage compensation. We show that TRA-1 binds to the consensus site in the xol-1 promoter in vitro and inhibits the expression of xol-1 in XX animals in vivo. Furthermore, inactivation of tra-1 enhances, whereas hyperactivation of tra-1 suppresses, lethality in animals with elevated xol-1 activity. These data imply the existence of a regulatory feedback loop within the C. elegans sex-determination and dosage-compensation cascade that ensures the accurate dose of X-linked genes in cells destined to adopt hermaphrodite fate."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.034637"xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Vellai T."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Stetak A."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Csankovszki G."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Takacs-Vellai K."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Blauwkamp T.A."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Hargitai B."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/author | "Kutnyanszky V."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/pages | "3881-3887"xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/title | "xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1."xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/19906855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19906855 |
| http://purl.uniprot.org/citations/19906855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19906855 |
| http://purl.uniprot.org/uniprot/#_P34691-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_P34704-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_P34708-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_H2L280-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_P41830-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_Q23229-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_P49594-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |
| http://purl.uniprot.org/uniprot/#_Q65ZB2-mappedCitation-19906855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19906855 |