| http://purl.uniprot.org/citations/19907433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19907433 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies reported an association with multiple sclerosis (MS) of distinct HLA-class I markers, namely HLA-A*02, HLA-Cw*05 and MOG-142L. In this work, we tested the association with MS of A*02 and Cw*05 in 1273 Italian MS patients and 1075 matched controls, which were previously analyzed for MOG-142, and explored the relationship among these three markers in modulating MS risk. HLA-A*02 conferred a statistically robust MS protection (odds ratio, OR=0.61; 95% confidence intervals, CI=0.51-0.72, P<10(-9)), which was independent of DRB1*15 and of any other DRB1* allele and remained similar after accounting for the other two analyzed class I markers. Conversely, the protective effect we previously observed for MOG-142L was secondary to its linkage disequilibrium with A*02. Cw*05 was not associated considering the whole sample, but its presence significantly enhanced the protection in the HLA-A*02-positive group, independently of DRB1: the OR conferred by A*02 in Cw*05-positive individuals (0.22, 95% CI=0.13-0.38) was significantly lower than in Cw*05-negative individuals (0.69, 95% CI=0.58-0.83) with a significant (P=4.94 x 10(-5)) multiplicative interaction between the two markers. In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1*03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2009.101"xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Barizzone N."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "D'Alfonso S."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Galimberti D."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Scarpini E."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Visconti A."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Bergamaschi L."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Bergamaschi R."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Dametto E."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Fasano M.E."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Guerini F.R."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Leone M.A."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Naldi P."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Salvetti M."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Corrado L."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Monaco F."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Agliardi C."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Caputo D."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Momigliano-Richiardi P."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Bolognesi E."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Ferrante D."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/author | "Vercellino M."xsd:string |
| http://purl.uniprot.org/citations/19907433 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |