| http://purl.uniprot.org/citations/19910490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19910490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19910490 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth factor stimulation induces the formation of dynamic actin structures known as dorsal ruffles. Mammalian actin-binding protein-1 (mAbp1) is an actin-binding protein that has been implicated in regulating clathrin-mediated endocytosis; however, a role for mAbp1 in regulating the dynamics of growth factor-induced actin-based structures has not been defined. Here we show that mAbp1 localizes to dorsal ruffles and is necessary for platelet-derived growth factor (PDGF)-mediated dorsal ruffle formation. Despite their structural similarity, we find that mAbp1 and cortactin have nonredundant functions in the regulation of dorsal ruffle formation. mAbp1, like cortactin, is a calpain 2 substrate and the preferred cleavage site occurs between the actin-binding domain and the proline-rich region, generating a C-terminal mAbp1 fragment that inhibits dorsal ruffle formation. Furthermore, mAbp1 directly interacts with the actin regulatory protein WASp-interacting protein (WIP) through its SH3 domain. Finally, we demonstrate that the interaction between mAbp1 and WIP is important in regulating dorsal ruffle formation and that WIP-mediated effects on dorsal ruffle formation require mAbp1. Taken together, these findings identify a novel role for mAbp1 in growth factor-induced dorsal ruffle formation through its interaction with WIP."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-02-0106"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-02-0106"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Huttenlocher A."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Huttenlocher A."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Cortesio C.L."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Cortesio C.L."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Bennin D.A."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Bennin D.A."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Perrin B.J."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/author | "Perrin B.J."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/pages | "186-197"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/pages | "186-197"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/title | "Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/title | "Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation."xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19910490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19910490 |
| http://purl.uniprot.org/citations/19910490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19910490 |