| http://purl.uniprot.org/citations/19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19910549 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and purposeEmerging evidence suggests that mitochondrial damage-mediated neuronal apoptosis is a major contributor to neonatal hypoxic-ischemic (H-I) brain injury. This study was performed to determine whether targeted inhibition of the apoptotic protease activating factor-1 (Apaf-1) signaling pathway downstream of mitochondrial damage confers neuroprotection in rodent models of neonatal H-I.MethodsH-I was induced in 7-day-old (P7) transgenic mice overexpressing the specific Apaf-1-inhibitory protein AIP. Apaf-1 inhibition was also achieved in P7 rats by protein transduction-enhanced delivery of recombinant AIP. Pups were euthanized 6 to 24 hours after H-I for assessing caspase activation and mitochondrial release of cytochrome c and AIF, and 7 days after H-I for analyzing brain tissue damage. Sensorimotor functions were assessed in rats up to 4 weeks after H-I.ResultsTransgenic overexpression of AIP protected against H-I brain injury, resulting in attenuated activation of caspase-9 and caspase-3, and attenuated brain tissue loss. In neonatal H-I rats, intraperitoneal injection of TAT-AIP, but not the control proteins TAT-GFP or AIP, decreased caspase activation and brain damage and improved neurological functions. Neuroprotection conferred by AIP was also associated with significantly reduced release of cytochrome c and AIF from mitochondria.ConclusionsThe Apaf-1 signaling pathway, which transmits cell death signals after mitochondrial damage to effector caspases, may be a legitimate therapeutic target for the treatment of neonatal H-I brain injury."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.org/dc/terms/identifier | "doi:10.1161/strokeaha.109.561852"xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Liang W."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Cao G."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Stetler R.A."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/author | "Vosler P."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/name | "Stroke"xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/pages | "166-172"xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/title | "Neuroprotection against hypoxic-ischemic brain injury by inhibiting the apoptotic protease activating factor-1 pathway."xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/19910549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19910549 |
| http://purl.uniprot.org/citations/19910549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19910549 |
| http://purl.uniprot.org/uniprot/#_D2CVN5-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK1-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK2-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK4-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK6-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK7-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |
| http://purl.uniprot.org/uniprot/#_A7YDK9-mappedCitation-19910549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19910549 |