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http://purl.uniprot.org/citations/19910613http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19910613http://www.w3.org/2000/01/rdf-schema#comment"

Rationale

Retrospective pharmacogenetic studies have questioned whether patients with asthma who are arginine homozygous at the beta(2-)adrenergic receptor (position 16) should use long-acting beta-agonists.

Objectives

To examine whether the response to salmeterol alone or in combination with an inhaled corticosteroid is influenced by beta-receptor polymorphisms.

Methods

Subjects using only as-needed albuterol were screened and completed two sequential open-label run-in periods (8 wk on as-needed albuterol; 8 wk on as-needed ipratropium). Five hundred forty-four subjects were randomized by Arg16Gly genotype to salmeterol alone or with fluticasone propionate for 16 weeks. Change from baseline in morning peak expiratory flow was the primary endpoint.

Measurements and main results

Lung function responses were sustained over treatment and no statistically significant changes from baseline between genotypes within treatments were observed. Overall mean changes in morning peak flow for salmeterol with fluticasone propionate were 32.6 L/min (Arg/Arg vs. Gly/Gly, 95% confidence interval [CI], -6.3, 22.1), 25.9 L/min (Arg/Arg vs. Arg/Gly, 95% CI, -7.1, 21.3), and 24.9 L/min (Arg/Gly vs. Gly/Gly, 95% CI, -13.0, 14.6), and for salmeterol alone were 19.4 L/min (Arg/Arg vs. Gly/Gly, 95% CI, -1.7, 21.4), 24.6 L/min (Arg/Arg vs. Arg/Gly, 95% CI, -13.0, 10.6), and 12.4 L/min (Arg/Gly vs. Gly/Gly, 95% CI, -0.2, 22.3) for Arg/Arg, Arg/Gly, and Gly/Gly genotypes, respectively. Other measures of asthma control showed similar responses.

Conclusions

The results showed no evidence of a pharmacogenetic effect of beta-receptor variation on salmeterol response. Clinical trial registered with www.clinicaltrials.gov (NCT 00102882)."xsd:string
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http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Kraft M."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Meyers D.A."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Bleecker E.R."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Anderson W.H."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Ortega H.G."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Yancey S.W."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Corren J."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Emmett A.H."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/author"Nelson H.S."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/name"Am J Respir Crit Care Med"xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/pages"676-687"xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/title"Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate."xsd:string
http://purl.uniprot.org/citations/19910613http://purl.uniprot.org/core/volume"181"xsd:string
http://purl.uniprot.org/citations/19910613http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19910613
http://purl.uniprot.org/citations/19910613http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19910613
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http://purl.uniprot.org/uniprot/#_Q9BYZ0-mappedCitation-19910613http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19910613
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http://purl.uniprot.org/uniprot/X5DQM5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19910613
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