| http://purl.uniprot.org/citations/19911011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19911011 | http://www.w3.org/2000/01/rdf-schema#comment | "Coronary artery spasm has an important function in the etiology of variant angina and other acute coronary syndromes. Abnormal activation of Rho-family GTPases has been observed in cardiovascular disorders, but the function of genetic variability in Rho-family GTPases remains to be evaluated in cardiovascular disorders. We examined the genetic variability of Rho-family GTPases and their regulators in coronary artery spasm. We performed a comprehensive candidate gene analysis of 67 single nucleotide polymorphisms with amino-acid substitution in Rho-family GTPases and their regulators in 103 unrelated Japanese patients with acetylcholine-induced coronary artery spasm and 102 control Japanese subjects without acetylcholine-induced coronary artery spasm. We noted an association of the single nucleotide polymorphism of ARHGAP9 (rs11544238, Ala370Ser) with coronary artery spasm (odds ratio =2.67). We found that ARHGAP9 inactivated Rac as RacGAP and that the mRNA level of ARHGAP9 was strongly detected in hematopoietic cells. ARHGAP9 negatively regulated cell migration. The Ala370Ser polymorphism counteracted ARHGAP9-reduced cell migration, spreading and adhesion. The Ala370Ser polymorphism in the ARHGAP9 gene is associated with coronary artery spasm. These data suggest that the polymorphism of ARHGAP9 has a critical function in the infiltration of hematopoietic cells into the endothelium and inflammation leading to endothelial dysfunction."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.org/dc/terms/identifier | "doi:10.1038/jhg.2009.120"xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Itoh T."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Amano M."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Hirayama H."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Morita Y."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Takefuji M."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Yokota M."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Izawa H."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Asano H."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Naoe T."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Katsumi A."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Takatsu F."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/author | "Hirashiki A."xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/name | "J Hum Genet"xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/pages | "42-49"xsd:string |
| http://purl.uniprot.org/citations/19911011 | http://purl.uniprot.org/core/title | "Mutation of ARHGAP9 in patients with coronary spastic angina."xsd:string |