| http://purl.uniprot.org/citations/19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19915059 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-21 has antitumor activity through actions on NK cells and CD8(+) T cells, and is currently in clinical development for the treatment of cancer. However, no studies have addressed the role of endogenous IL-21 in tumor immunity. In this study, we have studied both primary and secondary immune responses in IL-21(-/-) and IL-21R(-/-) mice against several experimental tumors. We found intact immune surveillance toward methylcholanthrene-induced sarcomas in IL-21(-/-) and IL-21R(-/-) mice compared with wild-type mice and B16 melanomas showed equal growth kinetics and development of lung metastases. IL-21R(-/-) mice showed competent NK cell-mediated rejection of NKG2D ligand (Rae1beta) expressing H-2b(-) RMAS lymphomas and sustained transition to CD8(+) T cell-dependent memory against H-2b(+) RMA lymphomas. alpha-Galactosylceramide stimulation showed equal expansion and activation of NKT and NK cells and mounted a powerful antitumor response in the absence of IL-21 signaling, despite reduced expression of granzyme B in NKT, NK, and CD8(+) T cells. Surprisingly, host IL-21 significantly restricted the expansion of Ag-specific CD8(+) T cells and inhibited primary CD8(+) T cell immunity against OVA-expressing EG7 lymphomas, as well as the secondary expansion of memory CD8(+) T cells. However, host IL-21 did not alter the growth of less immunogenic MC38 colon carcinomas with dim OVA expression. Overall, our results show that endogenous IL-21/IL-21R is not required for NK, NKT, and CD8(+) T cell-mediated tumor immunity, but restricts Ag-specific CD8(+) T cell expansion and rejection of immunogenic tumors, indicating novel immunosuppressive actions of this cytokine."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0902697"xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Sivakumar P.V."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Uldrich A.P."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Skak K."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "McLaughlin N."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Coquet J.M."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/author | "Sondergaard H."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/pages | "7326-7336"xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/title | "Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity."xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19915059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19915059 |
| http://purl.uniprot.org/citations/19915059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19915059 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP02-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_A5J0L5-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_E9PX58-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_Q3UBS8-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_Q3TA82-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_Q3TAI3-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |
| http://purl.uniprot.org/uniprot/#_Q5SUE2-mappedCitation-19915059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915059 |