| http://purl.uniprot.org/citations/19915515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19915515 | http://www.w3.org/2000/01/rdf-schema#comment | "Ischemia-reperfusion injury (IRI) is a leading cause of acute tubular necrosis (ATN) and delayed graft function in transplanted organs. Up-regulation of matrix metalloproteinases (MMPs) propagates the microinflammatory response that drives IRI. This study sought to determine the specific effects of Marimastat (Vernalis, BB-2516), a broad spectrum MMP and TNF-alpha-converting enzyme inhibitor, on IRI-induced ATN. Mice were pretreated with Marimastat or methylcellulose vehicle for 4 d before surgery. Renal pedicles were bilaterally occluded for 30 min and allowed to reperfuse for 24 h. Baseline creatinine levels were consistent between experimental groups; however, post-IRI creatinine levels were 4-fold higher in control mice (p < 0.0001). The mean difference between the post-IRI histology grades of Marimastat-treated and control kidneys was 1.57 (p = 0.003), demonstrating more severe damage to control kidneys. Post-IRI mean (+/-SEM) MMP-2 activity rose from baseline levels in control mice (3.62 +/-0.99); however, pretreated mice presented only a slight increase in mean MMP-2 activity (1.57 +/-0.72) (p < 0.001). In conclusion, these data demonstrate that MMP inhibition is associated with a reduction of IRI in a murine model."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.org/dc/terms/identifier | "doi:10.1203/pdr.0b013e3181ca0aa2"xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Le H.D."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Moses M.A."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Puder M."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Nose V."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Christison-Lagay E.R."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Doiron R.J."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/author | "Novak K.B."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/name | "Pediatr Res"xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/pages | "257-262"xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/title | "Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury."xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/19915515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19915515 |
| http://purl.uniprot.org/citations/19915515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19915515 |
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| http://purl.uniprot.org/uniprot/#_P33434-mappedCitation-19915515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915515 |
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| http://purl.uniprot.org/uniprot/#_Q6GXA5-mappedCitation-19915515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915515 |
| http://purl.uniprot.org/uniprot/Q75UT7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19915515 |
| http://purl.uniprot.org/uniprot/Q6GXA5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19915515 |
| http://purl.uniprot.org/uniprot/P33434 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19915515 |
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