http://purl.uniprot.org/citations/19915558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19915558 | http://www.w3.org/2000/01/rdf-schema#comment | "RME-1/EHD1 (receptor mediated endocytosis/Eps15 homology-domain containing 1) family proteins are key residents of the recycling endosome, which are required for endosome-to-plasma membrane transport in Caenorhabditis elegans and mammals. Recent studies suggest similarities between the RME-1/EHD proteins and the Dynamin GTPase superfamily of mechanochemical pinchases, which promote membrane fission. Here we show that endogenous C. elegans AMPH-1, the only C. elegans member of the Amphiphysin/BIN1 family of BAR (Bin1-Amphiphysin-Rvs161p/167p)-domain-containing proteins, colocalizes with RME-1 on recycling endosomes in vivo, that amph-1-deletion mutants are defective in recycling endosome morphology and function, and that binding of AMPH-1 Asn-Pro-Phe(Asp/Glu) sequences to the RME-1 EH-domain promotes the recycling of transmembrane cargo. We also show a requirement for human BIN1 (also known as Amphiphysin 2) in EHD1-regulated endocytic recycling. In vitro, we find that purified recombinant AMPH-1-RME-1 complexes produce short, coated membrane tubules that are qualitatively distinct from those produced by either protein alone. Our results indicate that AMPH-1 and RME-1 cooperatively regulate endocytic recycling, probably through functions required for the production of cargo carriers that exit the recycling endosome for the cell surface."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1986"xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Patel K."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Caplan S."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Carr C.M."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/author | "Pant S."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/pages | "1399-1410"xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/title | "AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling."xsd:string |
http://purl.uniprot.org/citations/19915558 | http://purl.uniprot.org/core/volume | "11"xsd:string |
http://purl.uniprot.org/citations/19915558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19915558 |
http://purl.uniprot.org/citations/19915558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19915558 |
http://purl.uniprot.org/uniprot/G5EFP1#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/G5EEU7#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/Q23146#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/G5ECC3#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/Q8WSP1#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/Q9N5B7#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/Q21004#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/Q86S80#attribution-B3A6B29BD79B24D82FACC7920714A48D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19915558 |
http://purl.uniprot.org/uniprot/#_A0A2C9C352-mappedCitation-19915558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19915558 |