| http://purl.uniprot.org/citations/19915568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19915568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19915568 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 1 beta (IL-1 beta) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-kappaB and subsequent processing of pro-IL-1 beta by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1 beta are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-mediated activation of NF-kappaB required the signaling adaptor MAVS and a complex of the adaptors CARD9 and Bcl-10, RIG-I also bound to the adaptor ASC to trigger caspase-1-dependent inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish RIG-I as a sensor able to activate the inflammasome in response to certain RNA viruses."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1824"xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1824"xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Peschel C."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Peschel C."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Roth S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Roth S."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Barchet W."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Barchet W."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Gross O."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Gross O."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Bscheider M."xsd:string |
| http://purl.uniprot.org/citations/19915568 | http://purl.uniprot.org/core/author | "Bscheider M."xsd:string |