| http://purl.uniprot.org/citations/19915574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19915574 | http://www.w3.org/2000/01/rdf-schema#comment | "The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.489"xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Castro M."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Levine A."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Taylor K."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Heath S."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Barrett J.C."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Ghori J."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Xavier R.J."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Brant S.R."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Datta L.W."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Duerr R.H."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Fisher S.A."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Green T."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Griffiths A.M."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Jewell D."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Mathew C.G."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Nicolae D.L."xsd:string |
| http://purl.uniprot.org/citations/19915574 | http://purl.uniprot.org/core/author | "Onnie C.M."xsd:string |