| http://purl.uniprot.org/citations/19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19917255 | http://www.w3.org/2000/01/rdf-schema#comment | "Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic B-Raf is unknown. Here we show that the proto-oncogene C-Raf paradoxically inhibits B-Raf(V600E) kinase activity through the formation of B-Raf(V600E)-C-Raf complexes. Although all Raf family members associate with oncogenic B-Raf, this inhibitory effect is specific to C-Raf. Indeed, a B-Raf(V600E) isoform with impaired ability to interact with C-Raf exhibits elevated oncogenic potential. Human melanoma cells expressing B-Raf(V600E) display a reduced C-Raf:B-Raf ratio, and further suppression of C-Raf increases MAPK activation and proliferation. Conversely, ectopic C-Raf expression lowers ERK phosphorylation and proliferation. Moreover, both oncogenic Ras and Sorafenib stabilize B-Raf(V600E)-C-Raf complexes, thereby impairing MAPK activation. This inhibitory function of C-Raf on B-Raf(V600E)-mediated MAPK activation may explain the lack of co-occurrence of B-Raf(V600E) and oncogenic Ras mutations, and influence the successful clinical development of small molecule inhibitors for B-Raf(V600E)-driven cancers."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.10.017"xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/author | "Tuveson D.A."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/author | "DeNicola G.M."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/author | "Winter S.P."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/author | "Karreth F.A."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/pages | "477-486"xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/title | "C-Raf inhibits MAPK activation and transformation by B-Raf(V600E)."xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/19917255 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19917255 |
| http://purl.uniprot.org/citations/19917255 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19917255 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L5-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z559-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_A1QJE5-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_B4E1N6-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_B4DHN0-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_B4E0X2-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_L7RRS6-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_L7RXH5-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_P27361-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_Q1HBJ4-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |
| http://purl.uniprot.org/uniprot/#_P04049-mappedCitation-19917255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917255 |