| http://purl.uniprot.org/citations/19917778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19917778 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell activation factor of the TNF family (BAFF) activates noncanonical nuclear factor kappaB (NF-kappaB) heterodimers that promote B cell survival. We show that although MALT1 is largely dispensable for canonical NF-kappaB signaling downstream of the B cell receptor, the absence of MALT1 results in impaired BAFF-induced phosphorylation of NF-kappaB2 (p100), p100 degradation, and RelB nuclear translocation in B220(+) B cells. This corresponds with impaired survival of MALT1(-/-) marginal zone (MZ) but not follicular B cells in response to BAFF stimulation in vitro. MALT1(-/-) MZ B cells also express higher amounts of TRAF3, a known negative regulator of BAFF receptor-mediated signaling, and TRAF3 was found to interact with MALT1. Furthermore, phenotypes associated with overexpression of BAFF, including increased MZ B cell numbers, elevated serum immunoglobulin titers, and spontaneous germinal center formation, were found to be dependent on B cell-intrinsic MALT1 expression. Our results demonstrate a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20091802"xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Ward L.A."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "McCarthy D."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Gommerman J.L."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Quintela-Fandino M."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Vu F."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/author | "Tusche M.W."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/pages | "2671-2683"xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/title | "Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets."xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://purl.uniprot.org/core/volume | "206"xsd:string |
| http://purl.uniprot.org/citations/19917778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19917778 |
| http://purl.uniprot.org/citations/19917778 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19917778 |
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| http://purl.uniprot.org/uniprot/#_B7ZWE5-mappedCitation-19917778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917778 |
| http://purl.uniprot.org/uniprot/#_Q3THY9-mappedCitation-19917778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917778 |
| http://purl.uniprot.org/uniprot/#_Q3U2H2-mappedCitation-19917778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19917778 |