| http://purl.uniprot.org/citations/19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19919107 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease and other tauopathies are characterized by the intracellular accumulation of insoluble filaments of the microtubule-associated protein tau. The six canonical tau isoforms in the adult brain consist of an N-terminal "projection" domain followed by a proline-rich region, a microtubule-binding repeat region, and a C-terminal tail. However, alternative splicing in exon 6 produces an additional set of tau isoforms, termed 6D and 6P, which contain only the N-terminus and part of the proline-rich region. We have previously shown that constructs representing N-terminal fragments of tau, which resemble the naturally occurring 6P and 6D isoforms, inhibit polymerization of the full-length protein in an in vitro filament formation assay and traced the inhibitory activity to amino acids 18-42. Here we report that 6P and 6D tau isoforms inhibit polymerization of full-length tau (hTau40) in a similar manner, likely by stabilizing full-length tau in a soluble conformation. The absence of exons 2 and 3 decreased the effectiveness of the 6D isoforms but not the 6P variants or the N-terminal tau fragments from our previous study, indicating that the 18-42 region is not the sole determinant of inhibitory ability. Finally, this paper demonstrates that inhibition is blocked by pseudophosphorylation of tyrosines 18 and 29, providing a potential link between tyrosine phosphorylation and disease progression. Taken together, these results indicate that the 6P/6D isoforms are potential endogenous inhibitors of tau filament formation and suggest a mechanism by which this ability may be disrupted in disease."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi901304u"xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Silva A."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Andreadis A."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Binder L.I."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Horowitz P.M."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Lapointe N.E."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/author | "Guillozet-Bongaarts A.L."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/pages | "12290-12297"xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/title | "Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro."xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/19919107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19919107 |
| http://purl.uniprot.org/citations/19919107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19919107 |
| http://purl.uniprot.org/uniprot/#_B4DSE3-mappedCitation-19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919107 |
| http://purl.uniprot.org/uniprot/#_B3KTM0-mappedCitation-19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919107 |
| http://purl.uniprot.org/uniprot/#_B4DSB3-mappedCitation-19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919107 |
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| http://purl.uniprot.org/uniprot/#_T1SGS4-mappedCitation-19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919107 |
| http://purl.uniprot.org/uniprot/#_Q96N45-mappedCitation-19919107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919107 |
| http://purl.uniprot.org/uniprot/P10636 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19919107 |
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