| http://purl.uniprot.org/citations/19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19919528 | http://www.w3.org/2000/01/rdf-schema#comment | "High tissue insulin-like growth factor binding protein-3 (IGFBP-3) expression in breast cancers is associated in some studies with rapid growth and poor outcome. This study examined the effects of endogenous IGFBP-3 in Hs578T breast cancer cells, which are IGF-unresponsive and grow aggressively despite relatively high IGFBP-3 expression. IGFBP-3 downregulation using siRNA was associated with increases in DNA synthesis, the percentage of cells in S phase and viable cell numbers, accompanied by increases in cyclins A and D1, a decrease in p27 expression, and increased phosphorylation of retinoblastoma (Rb) on Ser795. Downregulation of IGFBP-3 inhibited extracellular signal-regulated kinase (ERK) activation and cell migration in a monolayer wound healing assay. These results indicate that endogenous IGFBP-3 is anti-proliferative and pro-migratory in Hs578T cells and that these effects are IGF-independent. Poor outcome in breast tumours expressing high levels of IGFBP-3 may be due to the effects of IGFBP-3 on cell migration rather than cell growth."xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.org/dc/terms/identifier | "doi:10.3109/08977190903185032"xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/author | "Baxter R.C."xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/author | "Schedlich L.J."xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/author | "O'Han M.K."xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/pages | "394-408"xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/title | "Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/19919528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19919528 |
| http://purl.uniprot.org/citations/19919528 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KRZ1-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KRJ8-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KVF9-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_A6XNC9-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_A6XND0-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_A6XND1-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B4DP07-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B4DN53-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KPF0-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KTQ0-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KTS0-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |
| http://purl.uniprot.org/uniprot/#_B3KTS7-mappedCitation-19919528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19919528 |