DESCRIBE <http://purl.uniprot.org/citations/19919819>

Subject	Predicate	Object
http://purl.uniprot.org/citations/19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19919819	http://www.w3.org/2000/01/rdf-schema#comment	" Objective 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes (LTs), that might promote carcinogenesis. We investigated 5-LO expression and examined whether the 5-LO pathway is associated with the proliferation of human brain tumors. Methods We immunohistochemically evaluated the profile of 5-LO expression in various types of brain tumors obtained from 42 patients, and examined the proliferative effects of the 5-LO pathway in human glioma cell lines using a proliferation assay. Results Immunohistochemistry of glioblastomas, astrocytomas, meningiomas, medulloblastomas, craniopharyngiomas, ependymomas, neurinomas, oligodendrogliomas, malignant lymphomas, dysembryoplastic neuroepithelial and metastatic brain tumors revealed 5-LO expression in the cytoplasm and nuclei or nuclear envelopes of tumor cells. The 5-LO inhibitor A861 and the LTA4 hydrolase inhibitor Bestatin dose-dependently suppressed the proliferation of A172 cells, a glioma cell line. Conclusions We confirmed the expression of 5-LO in various human brain tumors and demonstrated the partial suppression of tumor growth by inhibitors of the 5-LO-LTA4 hydrolase pathway in human glioma cell lines. The 5-LO-LTA4 pathway might play roles in the proliferation of human glioma cells."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.org/dc/terms/identifier	"doi:10.5414/npp28445"xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Ishii K."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Matsuo M."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Kan Y."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Yonemitsu N."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Hamasaki Y."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/author	"Zaitsu M."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/date	"2009"xsd:gYear
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/name	"Clin Neuropathol"xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/pages	"445-452"xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/title	"5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines."xsd:string
http://purl.uniprot.org/citations/19919819	http://purl.uniprot.org/core/volume	"28"xsd:string
http://purl.uniprot.org/citations/19919819	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/19919819
http://purl.uniprot.org/citations/19919819	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/19919819
http://purl.uniprot.org/uniprot/#_A0A140VK27-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_B4DVZ8-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_B4DEH5-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_P09917-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_P09960-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_I0CLG0-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_Q59ES1-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_Q49AK0-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819
http://purl.uniprot.org/uniprot/#_Q59H13-mappedCitation-19919819	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/19919819