| http://purl.uniprot.org/citations/19922436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19922436 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThrombotic thrombocytopenic purpura (TTP) is a rare, acute, life-threatening disorder, associated with a deficiency in ADAMTS 13. The majority of acute, idiopathic, adult TTP cases are associated with anti-ADAMTS 13 IgG antibodies. However, the factor(s) precipitating an acute TTP episode are not always obvious; indeed, a multifactorial etiology is likely.Objectives and methodsDNA was used for human leukocyte antigen (HLA) class II typing, using polymerase chain reaction (PCR)-sequence-specific primer and PCR-sequence-specific oligonucleotide probe to methodology to investigate 50 European acquired idiopathic TTP cases.ResultsThere was an increase in the frequency of HLA-DQB1*0301 (HLA-DQ7) in patients with TTP as compared with controls [58.0% vs. 34.5% (P=0.048)]. The frequencies of HLA-DRB1*11 and HLA-DRB3* were also significantly increased in TTP patients as compared with controls [44.0% vs. 12.0% (P=0.0024) and 84.0% vs. 58.0% (P=0.024)], although it remains uncertain whether susceptibility is influenced by HLA-DQ or HLA-DR molecules or other genes in this haplotype. The frequencies of HLA-DRB1*04 and HLA-DRB4 (HLA-DR53) were significantly decreased in the patient group as compared with controls [10.0% vs. 35.0% and 26.0% vs. 61.5% (P=0.0096 and P=0.0024, respectively)], and may have a protective effect against the development of TTP.ConclusionAnalysis identified HLA class II types associated with susceptibility to and a protective effect against the development of acute acquired TTP in European patients. This provides the first description of a genetic factor predicting the risk of developing acquired antibody-mediated TTP."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1538-7836.2009.03692.x"xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "Patel R."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "Scully M."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "Brown C.J."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "Brown J."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "McDonald V."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/author | "Machin S."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/name | "J Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/pages | "257-262"xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/title | "Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link."xsd:string |
| http://purl.uniprot.org/citations/19922436 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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