| http://purl.uniprot.org/citations/19922874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19922874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19922874 | http://www.w3.org/2000/01/rdf-schema#comment | "The Arp2/3 complex regulates endocytosis, sorting, and trafficking, yet the Arp2/3-stimulating factors orchestrating these distinct events remain ill defined. WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) is an Arp2/3 activator with unknown function that was duplicated during primate evolution. We demonstrate that WASH associates with tubulin and localizes to early endosomal subdomains, which are enriched in Arp2/3, F-actin, and retromer components. Although WASH localized with activated receptors, it was not essential for endocytosis. However, WASH did regulate retromer-mediated retrograde CI-MPR trafficking, which required its association with endosomes, Arp2/3-directed F-actin regulation, and tubulin interaction. Moreover, WASH exists in a multiprotein complex containing FAM21, which links WASH to endosomes and is required for WASH-dependent retromer-mediated sorting. Significantly, without WASH, retromer tubulation was exaggerated, supporting a model wherein WASH links retromer-mediated cargo containing tubules to microtubules for Golgi-directed trafficking and generates F-actin-driven force for tubule scission."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.09.009"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.09.009"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/pages | "699-711"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/pages | "699-711"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/title | "A FAM21-containing WASH complex regulates retromer-dependent sorting."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/title | "A FAM21-containing WASH complex regulates retromer-dependent sorting."xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19922874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19922874 |
| http://purl.uniprot.org/citations/19922874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19922874 |
| http://purl.uniprot.org/citations/19922874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19922874 |
| http://purl.uniprot.org/citations/19922874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19922874 |
| http://purl.uniprot.org/uniprot/Q9Y4E1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19922874 |
| http://purl.uniprot.org/uniprot/A8K0Z3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19922874 |