| http://purl.uniprot.org/citations/19922876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19922876 | http://www.w3.org/2000/01/rdf-schema#comment | "Sumoylation is a reversible posttranslational modification that plays roles in many processes, including transcriptional regulation, cell division, chromosome integrity, and DNA damage response. Using a proteomics approach, we identified approximately 250 candidate targets of sumoylation in C. elegans. One such target is the cytoplasmic intermediate filament (cIF) protein named IFB-1, which is expressed in hemidesmosome-like structures in the worm epidermis and is essential for embryonic elongation and maintenance of muscle attachment to the cuticle. In the absence of SUMO, IFB-1 formed ectopic filaments and protein aggregates in the lateral epidermis. Moreover, depletion of SUMO or mutation of the SUMO acceptor site on IFB-1 resulted in a reduction of its cytoplasmic soluble pool, leading to a decrease in its exchange rate within epidermal attachment structures. These observations indicate that SUMO regulates cIF assembly by maintaining a cytoplasmic pool of nonpolymerized IFB-1, and that this is necessary for normal IFB-1 function."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.10.005"xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Chisholm A.D."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Denison C."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Broday L."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Bening-Abu-Shach U."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/author | "Kaminsky R."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/pages | "724-735"xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/title | "SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19922876 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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