| http://purl.uniprot.org/citations/19923443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19923443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19923443 | http://www.w3.org/2000/01/rdf-schema#comment | "Hacs1, a SH3 and SAM domain-containing adaptor protein, is up-regulated by IL-4 in activated B cells and strongly expressed in dendritic cells. To elucidate the function of Hacs1 in immune regulation, we generated Hacs1(-/-) mice by deletion of the SH3 and SAM domains. Hacs1(-/-) mice were viable and fertile and had normal bone marrow B-cell development and normal splenic T- and B-cell populations. However, adult Hacs1(-/-) mice had increased peritoneal B1a cells (IgM(+)CD5(+)). On immunization with T-cell-independent antigen TNP-Ficoll, Hacs1(-/-) mice had increased production of anti-TNP IgM and IgG3. Purified splenic B cells from Hacs1(-/-) mice showed increased cell proliferation on BCR (B-cell receptor) stimulation. We further demonstrate that the Hacs1(-/-) B cells had increased global tyrosine phosphorylation, including tyrosine kinases Lyn and Akt. Both T-helper type 1 (T(h)1) and T-helper type 2 (T(h)2) humoral responses were enhanced in Hacs1(-/-) mice. In vitro bone marrow-derived Hacs1(-/-) dendritic cells showed increased IL-12 production on stimulation with ovalbumin (OVA). This study suggests that Hacs1 is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.-Wang, D., Stewart, A. K., Zhuang, L., Zhu, Y., Wang, Y., Shi, C., Keating, A., Slutsky, A., Zhang, H., Wen, X.-Y. Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-140806"xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-140806"xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Shi C."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Shi C."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhuang L."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Zhuang L."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Stewart A.K."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Stewart A.K."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wen X.Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Wen X.Y."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Slutsky A."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Slutsky A."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Keating A."xsd:string |
| http://purl.uniprot.org/citations/19923443 | http://purl.uniprot.org/core/author | "Keating A."xsd:string |