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http://purl.uniprot.org/citations/19923718http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19923718http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19923718http://www.w3.org/2000/01/rdf-schema#comment"Filamin A (FLNa) is a large dimeric protein that binds to actin filaments via its actin-binding domain (ABD). The crystal structure of this domain was solved at 3.2 A resolution. The domain adopts a closed conformation typical of other ABDs, but also forms a dimer both in crystallization conditions and in solution. The structure shows the localization of the residues mutated in patients with periventricular nodular heterotopia or otopalatodigital syndrome. Structural analysis predicts that mutations in both types of disorder may affect actin binding."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.org/dc/terms/identifier"doi:10.1107/s0907444909037330"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.org/dc/terms/identifier"doi:10.1107/s0907444909037330"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/author"Ylanne J."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/author"Ylanne J."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/author"Ruskamo S."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/author"Ruskamo S."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/name"Acta Crystallogr. D"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/name"Acta Crystallogr. D"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/pages"1217-1221"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/pages"1217-1221"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/title"Structure of the human filamin A actin-binding domain."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/title"Structure of the human filamin A actin-binding domain."xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/19923718http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/19923718http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19923718
http://purl.uniprot.org/citations/19923718http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19923718
http://purl.uniprot.org/citations/19923718http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19923718
http://purl.uniprot.org/citations/19923718http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19923718
http://purl.uniprot.org/uniprot/P21333http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/19923718
http://purl.uniprot.org/uniprot/P21333#attribution-9EAB675F3F12BCF402F0FAEE22B48C73http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19923718