| http://purl.uniprot.org/citations/19930468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19930468 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation mechanisms of Src family kinases (SFKs) involve the dissociation of the intramolecular interaction between the Src homology (SH) 3 and kinase domain. This process is mediated by the intermolecular attack of outer ligands to the SH3 domain. By using a yeast two-hybrid screen, we isolated a relevant ligand involved in the activation mechanisms of SFKs. This molecule was found to be identical to a recently recognized kinetochore protein--designated as centromere protein (CENP)-V--which is required for the progression of mitosis. We show here that human CENP-V plays further roles in cell dynamics; the proline-rich region of human CENP-V associates with the SH3 domains of SFKs and potently activates SFKs, whereas another domain of CENP-V that possesses a highly conserved cysteine array confers the ability to associate with stabilized microtubules (MTs). Human CENP-V distributes to the cell protrusion and to the leading edge of migrating cells in response to external stimuli, and depletion of CENP-V by RNA interference significantly attenuates closure of a scratch wound. These findings indicate that human CENP-V is involved in directional cell motility as well as in the progression of mitosis, as a scaffolding molecule that links MTs and SFKs."xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2009.01355.x"xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/author | "Honda H."xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/author | "Honda Z."xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/pages | "1383-1394"xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/title | "Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction."xsd:string |
| http://purl.uniprot.org/citations/19930468 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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