| http://purl.uniprot.org/citations/19933379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19933379 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that Fms-like tyrosine kinase 3 ligand (Flt3-L) reversed airway hyperresponsiveness (AHR) and airway inflammation, and increased the number of regulatory CD11c(high)CD8α(high)CD11b(low) dendritic cells and CD4(+)CD25(+)ICOS(+)Foxp3(+)IL-10(+) T-regulatory cells in the lung of allergen-sensitized and -challenged mice. In this study, we evaluated the effect of Flt3-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS) proteins in the lungs of house dust mite (HDM)-sensitized and -challenged mice. BALB/c mice were sensitized and challenged with HDM, and AHR to methacholine was established. Mice were treated with Flt3-L (5 μg, intraperitoneal) daily for 10 days. Levels of IL-4, -5, -6, -8, and -13, and transforming growth factor (TGF)-β in the bronchoalveolar lavage fluid (BALF) were examined by ELISA. Flt3-L treatment reversed existing AHR to methacholine and substantially decreased eosinophils, neutrophils, IL-5, -6, -8, and IL-13, and TGF-β levels in the BALF. HDM-sensitized and -challenged mice showed a significant increase in lung CD4(+)IL-17(+)IL-23R(+)CD25⁻ T cells with high expression of retinoic acid-related orphan receptor (ROR)-γt transcripts. However, administration of Flt3-L substantially decreased the number of lung CD4(+)IL-17(+)IL-23R(+)CD25⁻ T cells, with significantly decreased expression of ROR-γt mRNA in these cells. HDM sensitization caused a significant increase in the expression of SOCS-1, -3, and -5 in the lung. Flt3-L treatment abolished the increase in SOCS-1 and SOCS-3 proteins, whereas SOCS-5 expression was significantly reduced. These data suggest that the therapeutic effect of Flt3-L in reversing the hallmarks of allergic asthma in a mouse model is mediated by decreasing IL-6 and TGF-β levels in the BALF, which, in turn, decrease CD4(+)IL-17(+)IL-23R(+)ROR-γt(+)CD25⁻ T cells and the expression of SOCS-1 and SOCS-3 in the lung of HDM-sensitized and -challenged mice."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2009-0241oc"xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "Shao Z."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "Agrawal D.K."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "McGee H.S."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "Agrawal T."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "Lorence L."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/author | "Stallworth A.L."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/pages | "520-529"xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/title | "Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice."xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/19933379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19933379 |
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| http://purl.uniprot.org/uniprot/O35716 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19933379 |
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