| http://purl.uniprot.org/citations/19933863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19933863 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion. In the present study, we find that STAP-2 expression affects Jurkat T cell migration after stromal cell-derived factor-1alpha (SDF-1alpha)-treatment. Furthermore, STAP-2-deficient T cells exhibit reduced cell migration after SDF-1alpha-treatment. Importantly, overexpression of STAP-2 in Jurkat T cells induces activation of small guanine triphosphatases, such as Rac1 and Cdc42. Regarding the mechanism for this effect, we found that STAP-2 associates with Vav1, the guanine-nucleotide exchanging factor for Rac1, and enhances downstream Vav1/Rac1 signaling. These results reveal a novel STAP-2-mediated mechanism for the regulation of SDF-1alpha-induced chemotaxis of T cells via activation of Vav1/Rac1 signaling."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0902096"xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Tsuji S."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Nanbo A."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Ikeda O."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/author | "Yamamoto C."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/pages | "7966-7974"xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/title | "Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells."xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19933863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19933863 |
| http://purl.uniprot.org/citations/19933863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19933863 |
| http://purl.uniprot.org/uniprot/#_Q8R0L1-mappedCitation-19933863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19933863 |
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| http://purl.uniprot.org/uniprot/Q9UGK3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19933863 |
| http://purl.uniprot.org/uniprot/Q8R0L1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19933863 |