| http://purl.uniprot.org/citations/19934321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19934321 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in a variety of cancer cells. The addition of ligand activates the receptor by inducing a conformational change in the receptor, which can be recapitulated by mutation. To investigate the role of activated PPARgamma signaling in breast cancer, we compared the function of a constitutively active PPARgamma (PgammaCA) mutant with the wild-type PPARgamma in ErbB2-induced mammary tumorigenesis in vivo. Tumor cells transduced with either PPARgamma or PgammaCA were implanted into immunocompetent FVB mice. Enhanced tumor growth was observed in PgammaCA-transduced cells, which was associated with increased angiogenesis and endothelial stem cells as evidenced by increased number of cells stained with von Willebrand factor, c-Kit, CD133, and CD31. Genome-wide expression profiling identified a group of genes within the angiogenesis pathway, including Angptl4, as targets of activated PPARgamma; PgammaCA also induced Angptl4 protein secretion in ErbB2-transformed mammary epithelial cells. Angptl4 promoted vascular endothelial cell migration; conversely, immunodepletion of Angptl4 reduced PgammaCA-mediated cellular migration. Collectively, these studies suggest that activated PPARgamma induces Angptl4 to promote tumor growth through enhanced angiogenesis in vivo."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-09-2067"xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Liang B."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Pestell R.G."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Casimiro M.C."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Hyslop T."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/author | "Ojeifo J.O."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/pages | "9236-9244"xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/title | "Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/19934321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19934321 |
| http://purl.uniprot.org/citations/19934321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19934321 |
| http://purl.uniprot.org/uniprot/#_Q07869-mappedCitation-19934321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19934321 |
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| http://purl.uniprot.org/uniprot/#_Q15648-mappedCitation-19934321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19934321 |
| http://purl.uniprot.org/uniprot/#_A0JLT2-mappedCitation-19934321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19934321 |
| http://purl.uniprot.org/uniprot/#_P37231-mappedCitation-19934321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19934321 |