| http://purl.uniprot.org/citations/19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19936020 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila, genes expressed in males tend to accumulate on autosomes and are underrepresented on the X chromosome. In particular, genes expressed in testis have been observed to frequently relocate from the X chromosome to the autosomes. The inactivation of X-linked genes during male meiosis (i.e., meiotic sex chromosome inactivation-MSCI) was first proposed to explain male sterility caused by X-autosomal translocation in Drosophila, and more recently it was suggested that MSCI might provide the conditions under which selection would favor the accumulation of testis-expressed genes on autosomes. In order to investigate the impact of MSCI on Drosophila testis-expressed genes, we performed a global gene expression analysis of the three major phases of D. melanogaster spermatogenesis: mitosis, meiosis, and post-meiosis. First, we found evidence supporting the existence of MSCI by comparing the expression levels of X- and autosome-linked genes, finding the former to be significantly reduced in meiosis. Second, we observed that the paucity of X-linked testis-expressed genes was restricted to those genes highly expressed in meiosis. Third, we found that autosomal genes relocated through retroposition from the X chromosome were more often highly expressed in meiosis in contrast to their X-linked parents. These results suggest MSCI as a general mechanism affecting the evolution of some testis-expressed genes."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000731"xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/author | "Long M."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/author | "Karr T.L."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/author | "Vibranovski M.D."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/author | "Lopes H.F."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/pages | "e1000731"xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/title | "Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes."xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/19936020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19936020 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4LGG1-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |
| http://purl.uniprot.org/uniprot/#_A1YJR7-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |
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| http://purl.uniprot.org/uniprot/#_A1YJS0-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |
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| http://purl.uniprot.org/uniprot/#_A1YJT1-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |
| http://purl.uniprot.org/uniprot/#_A1YJT3-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |
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| http://purl.uniprot.org/uniprot/#_A1YJU7-mappedCitation-19936020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19936020 |