| http://purl.uniprot.org/citations/19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19940151 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive responses to reduced oxygen availability. HIF-alpha subunits are stabilized under conditions of acute hypoxia. However, prolonged hypoxia leads to decay of HIF-1alpha but not HIF-2alpha protein levels by unknown mechanisms. Here, we identify Hsp70 and CHIP (carboxyl terminus of Hsc70-interacting protein) as HIF-1alpha-interacting proteins. Hsp70, through recruiting the ubiquitin ligase CHIP, promotes the ubiquitination and proteasomal degradation of HIF-1alpha but not HIF-2alpha, thereby inhibiting HIF-1-dependent gene expression. Disruption of Hsp70-CHIP interaction blocks HIF-1alpha degradation mediated by Hsp70 and CHIP. Inhibition of Hsp70 or CHIP synthesis by RNA interference increases protein levels of HIF-1alpha but not HIF-2alpha and attenuates the decay of HIF-1alpha levels during prolonged hypoxia. Thus, Hsp70- and CHIP-dependent ubiquitination represents a molecular mechanism by which prolonged hypoxia selectively reduces the levels of HIF-1alpha but not HIF-2alpha protein."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.068577"xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Pandey A."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Zhong J."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Luo W."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Chang R."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/pages | "3651-3663"xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/title | "Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha."xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/19940151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19940151 |
| http://purl.uniprot.org/citations/19940151 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19940151 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_A1XP52-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_A0A384P5G6-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_B7Z1V7-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_B7Z4T3-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_B7Z4V2-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |
| http://purl.uniprot.org/uniprot/#_B3KW07-mappedCitation-19940151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940151 |