| http://purl.uniprot.org/citations/19940171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19940171 | http://www.w3.org/2000/01/rdf-schema#comment | "There remains debate regarding the impact of cannabis on neuropsychiatric disorders. Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of cannabis, on heroin self-administration and drug-seeking behavior using an experimental rat model. CBD (5-20 mg/kg) did not alter stable intake of heroin self-administration, extinction behavior, or drug seeking induced by a heroin prime injection. Instead, it specifically attenuated heroin-seeking behavior reinstated by exposure to a conditioned stimulus cue. CBD had a protracted effect with significance evident after 24 h and even 2 weeks after administration. The behavioral effects were paralleled by neurobiological alterations in the glutamatergic and endocannabinoid systems. Discrete disturbances of AMPA GluR1 and cannabinoid type-1 receptor expression observed in the nucleus accumbens associated with stimulus cue-induced heroin seeking were normalized by CBD treatment. The findings highlight the unique contributions of distinct cannabis constituents to addiction vulnerability and suggest that CBD may be a potential treatment for heroin craving and relapse."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4291-09.2009"xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/author | "Ren Y."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/author | "Hurd Y.L."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/author | "Higuera-Matas A."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/author | "Morris C.V."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/author | "Whittard J."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/pages | "14764-14769"xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/title | "Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances."xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19940171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19940171 |
| http://purl.uniprot.org/citations/19940171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19940171 |
| http://purl.uniprot.org/uniprot/P19490#attribution-C339B88349B8FDA786EACDA356D1EB72 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19940171 |
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| http://purl.uniprot.org/uniprot/#_P19490-mappedCitation-19940171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19940171 |
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| http://purl.uniprot.org/uniprot/M0R5P7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19940171 |
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| http://purl.uniprot.org/uniprot/P19490 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19940171 |