| http://purl.uniprot.org/citations/19941887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19941887 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin C is a powerful antioxidant and its levels are decreased in Alzheimer's patients. Even sub-clinical vitamin C deficiency could impact disease development. To investigate this principle we crossed APP/PSEN1 transgenic mice with Gulo knockout mice unable to synthesize their own vitamin C. Experimental mice were maintained from 6 weeks of age on standard (0.33 g/L) or reduced (0.099 g/L) levels of vitamin C and then assessed for changes in behavior and neuropathology. APP/PSEN1 mice showed impaired spatial learning in the Barnes maze and water maze that was not further impacted by vitamin C level. However, long-term decreased vitamin C levels led to hyperactivity in transgenic mice, with altered locomotor habituation and increased omission errors in the Barnes maze. Decreased vitamin C also led to increased oxidative stress. Transgenic mice were more susceptible to the activity-enhancing effects of scopolamine and low vitamin C attenuated these effects in both genotypes. These data indicate an interaction between the cholinergic system and vitamin C that could be important given the cholinergic degeneration associated with Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pbb.2009.11.009"xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/author | "May J.M."xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/author | "McDonald M.P."xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/author | "Harrison F.E."xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/name | "Pharmacol Biochem Behav"xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/pages | "543-552"xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/title | "Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/19941887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19941887 |
| http://purl.uniprot.org/citations/19941887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19941887 |
| http://purl.uniprot.org/uniprot/#_P58710-mappedCitation-19941887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19941887 |
| http://purl.uniprot.org/uniprot/#_Q8K156-mappedCitation-19941887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19941887 |
| http://purl.uniprot.org/uniprot/#_Q8JZZ1-mappedCitation-19941887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19941887 |
| http://purl.uniprot.org/uniprot/Q8JZZ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19941887 |
| http://purl.uniprot.org/uniprot/P58710 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19941887 |
| http://purl.uniprot.org/uniprot/Q8K156 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19941887 |