| http://purl.uniprot.org/citations/19946272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19946272 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the transcription factor NF-kappaB and suppresses interleukin 10 (IL-10). Here we found that mice deficient in PDCD4 were protected from lipopolysaccharide (LPS)-induced death. The induction of NF-kappaB and IL-6 by LPS required PDCD4, whereas LPS enhanced IL-10 induction in cells lacking PDCD4. Treatment of human peripheral blood mononuclear cells with LPS resulted in lower PDCD4 expression, which was due to induction of the microRNA miR-21 via the adaptor MyD88 and NF-kappaB. Transfection of cells with a miR-21 precursor blocked NF-kappaB activity and promoted IL-10 production in response to LPS, whereas transfection with antisense oligonucleotides to miR-21 or targeted protection of the miR-21 site in Pdcd4 mRNA had the opposite effect. Thus, miR-21 regulates PDCD4 expression after LPS stimulation."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1828"xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "O'Neill L.A."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Johnson D.S."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Sheedy F.J."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Ruan Q."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Hennessy E.J."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "O'Leary J.J."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/author | "Palsson-McDermott E."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/pages | "141-147"xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/title | "Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21."xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/19946272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19946272 |
| http://purl.uniprot.org/citations/19946272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19946272 |
| http://purl.uniprot.org/uniprot/Q53EL6#attribution-E63CCC23553DB877974BC47E91212366 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19946272 |
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| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-19946272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19946272 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-19946272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19946272 |
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| http://purl.uniprot.org/uniprot/#_A0A494BA44-mappedCitation-19946272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19946272 |