| http://purl.uniprot.org/citations/19948740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19948740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19948740 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor 4 (TLR4) is unique among the Toll-like receptors in its ability to utilize TLR/IL1R-domain-containing adaptor protein (TIRAP), which recruits TLR4-MyD88 to phosphatidylinositol 4,5-bisphosphate (PIP(2))-rich sites on the plasma membrane, to activate NF-kappaB and MAPK pathways. Here, we show that AIP1 disrupts formation of the TLR4-TIRAP-MyD88 complex without directly binding to any of the complex components. AIP1 via its pleckstrin homology and C2 domains binds to phosphatidylinositol 4-phosphate, a lipid precursor of PIP(2). Knock-out of AIP1 in cells increases and overexpression of AIP1 reduces cellular PIP(2) levels. We further show that AIP1 is a novel GTPase-activating protein (GAP) for Arf6, a small GTPase regulating cellular PIP(2) production and formation of the TLR4-TIRAP-MyD88 complex. Thus, deletion of the GAP domain on AIP1 results in a loss of its ability to mediate the inhibition of Arf6- and TLR4-induced signaling events. We conclude that AIP1 functions as a novel Arf6-GAP to negatively regulate PIP(2)-dependent TLR4-TIRAP-MyD88 signaling."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.069385"xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.069385"xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Min W."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Min W."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Wan T."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/author | "Wan T."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/pages | "3750-3757"xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/pages | "3750-3757"xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/title | "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/title | "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/19948740 | http://purl.uniprot.org/core/volume | "285"xsd:string |