| http://purl.uniprot.org/citations/19949087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19949087 | http://www.w3.org/2000/01/rdf-schema#comment | "HSV-specific CD8(+) T cells provide constant immunosurveillance of HSV-1 latently infected neurons in sensory ganglia, and their functional properties are influenced by the presence of latent virus. In this study, we show that ganglionic HSV-specific CD8(+) T cells exhibit a higher functional avidity (ability to respond to low epitope density) than their counterparts in noninfected lungs, satisfying a need for memory effector cells that can respond to low densities of viral epitopes on latently infected neurons. We further show that lack of CD4(+) T cell help during priming leads to a transient inability to control latent virus, which was associated with a PD-1/PD-L1 mediated reduced functional avidity of ganglionic HSV-specific CD8(+) T cells. CD4(+) T cells are not needed to maintain CD8(+) T cell memory through 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0902373"xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Freeman M.L."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Hendricks R.L."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Lepisto A.J."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Frank G.M."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Sheridan B.S."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/author | "Cherpes T.L."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/pages | "277-286"xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/title | "Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency."xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/19949087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19949087 |
| http://purl.uniprot.org/citations/19949087 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19949087 |
| http://purl.uniprot.org/uniprot/#_Q02242-mappedCitation-19949087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19949087 |
| http://purl.uniprot.org/uniprot/#_Q544F3-mappedCitation-19949087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19949087 |
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| http://purl.uniprot.org/uniprot/Q9EP73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19949087 |
| http://purl.uniprot.org/uniprot/Q02242 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19949087 |
| http://purl.uniprot.org/uniprot/Q544F3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19949087 |