http://purl.uniprot.org/citations/19950592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19950592 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the possible mechanism of felodipine on experimental atheroselerosis formation in rats.MethodsThe rat model of atherosclerosis was established by the methods of intraperitoneal injection of Vitamin D3 and high-fat diet. Thirty male SD rats were randomly divided into normal group, atherosclerosis model group and felodipine treating group. At the end of 6 weeks, the expression of NF-kappaB (nuclear transcription fator-kappaB) in endothelial cells and smooth muscle cells of aorta were determined.ResultsThe positive rates of NF-kappaB in both atherosclerosis model group and felodipine treating group (46.59+/-5.68, 20.47+/-1.97) were higher than that of normal group (4.38+/-1.07, P<0.01). The expression of NF-kappaB in atherosclerosis model group was higher than that of felodipine treating group (P<0.01).ConclusionsThe mechanism of felodipine in relieving atheroselerosis may correlate with the inhibition of NF-kappaBp65 activation."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/author | "Nie H."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/author | "Du X.D."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/name | "Sichuan Da Xue Xue Bao Yi Xue Ban"xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/pages | "826-828"xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/title | "[Effect of felodipine on the expression of NF-kappaB in rat model of atherosclerosis]."xsd:string |
http://purl.uniprot.org/citations/19950592 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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