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http://purl.uniprot.org/citations/19950592http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19950592http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the possible mechanism of felodipine on experimental atheroselerosis formation in rats.

Methods

The rat model of atherosclerosis was established by the methods of intraperitoneal injection of Vitamin D3 and high-fat diet. Thirty male SD rats were randomly divided into normal group, atherosclerosis model group and felodipine treating group. At the end of 6 weeks, the expression of NF-kappaB (nuclear transcription fator-kappaB) in endothelial cells and smooth muscle cells of aorta were determined.

Results

The positive rates of NF-kappaB in both atherosclerosis model group and felodipine treating group (46.59+/-5.68, 20.47+/-1.97) were higher than that of normal group (4.38+/-1.07, P<0.01). The expression of NF-kappaB in atherosclerosis model group was higher than that of felodipine treating group (P<0.01).

Conclusions

The mechanism of felodipine in relieving atheroselerosis may correlate with the inhibition of NF-kappaBp65 activation."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/author"Cao Y."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/author"Nie H."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/author"Zhang S."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/author"Du X.D."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/name"Sichuan Da Xue Xue Bao Yi Xue Ban"xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/pages"826-828"xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/title"[Effect of felodipine on the expression of NF-kappaB in rat model of atherosclerosis]."xsd:string
http://purl.uniprot.org/citations/19950592http://purl.uniprot.org/core/volume"40"xsd:string
http://purl.uniprot.org/citations/19950592http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19950592
http://purl.uniprot.org/citations/19950592http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19950592
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http://purl.uniprot.org/uniprot/Q63369http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19950592
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http://purl.uniprot.org/uniprot/A6HVY6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19950592