| http://purl.uniprot.org/citations/19954752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19954752 | http://www.w3.org/2000/01/rdf-schema#comment | "Cathepsins are expressed in antigen-presenting cells (APC). These cathepsins are known to regulate antigen processing and degradation of the invariant chain (Ii) into the class II-associated Ii peptide (CLIP), which occupies the peptide-binding groove of the major histocompatibility complex (MHC) class II molecule. Previous studies have identified the serine carboxypeptidase cathepsin A (CatA) in various tissues and cells; however, it is not clear whether CatA is also expressed in primary human APC. We demonstrate the expression of CatA in B lymphoblastoid cells (BLC), primary human B cells, both subsets of myeloid dendritic cells (mDC1 and mDC2), as well as in plasmacytoid DC. PMSF or lactacystin-mediated inhibition of serine proteases in BLC-derived lysosomal proteases resulted in the inhibition of amino acid release from the C-terminal end of two model peptides. This inhibition did not occur by using a proline rich peptide. Our data suggest that CatA is involved in the C-terminal fine-tuning of antigenic T cell epitopes in human APC."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imlet.2009.11.010"xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Reich M."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Spindler K.D."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Kalbacher H."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Burster T."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Boehm B.O."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/author | "Burret M."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/pages | "143-147"xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/title | "Cathepsin A is expressed in primary human antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/19954752 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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